Abstract | OBJECTIVE: DESIGN: This study was a prospective, randomized, unblinded clinical trial with follow-up at 2 and 8 wks. Thirty patients (48 median nerves) with clinical and electrophysiologic evidence of carpal tunnel syndrome were included in the study. Patients were evaluated by use of clinical variables, a functional status scale, a symptom severity scale, and visual analog scale. A total of 48 median nerves were randomly assigned to one of two groups; group 1 received 40 mg of methylprednisolone acetate injected locally in the carpal tunnel, and group 2 received iontophoresis of dexamethasone sodium phosphate. Clinical variables and scales were evaluated at regular intervals: at the beginning and at the end of therapy in the second and eighth week. RESULTS: Twenty-seven patients (90%) were women and three patients (10%) were men. The mean age of patients was 48.0 +/- 8.2 (range, 29-61) yrs. There was a statistically significant improvement in the clinical examination variables, visual analog scale, symptom severity scale, and functional status scale scores of the patients in both of the treatment groups posttreatment (at 2 and 8 wks) compared with baseline (P < 0.05). However, there was a statistically significant difference between the values of the two group. A significant difference in mean symptom severity scale, functional status scale, and visual analog scale scores was found in second week and eighth week in the injection group compared with iontophoresis. CONCLUSION:
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Authors | Figen Gökoğlu, Gülin Fındıkoğlu, Z Rezan Yorgancoğlu, Müyesser Okumuş, Esma Ceceli, Seher Kocaoğlu |
Journal | American journal of physical medicine & rehabilitation
(Am J Phys Med Rehabil)
Vol. 84
Issue 2
Pg. 92-6
(Feb 2005)
ISSN: 0894-9115 [Print] United States |
PMID | 15668556
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Dexamethasone
- Methylprednisolone
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Topics |
- Adult
- Carpal Tunnel Syndrome
(drug therapy)
- Dexamethasone
(administration & dosage, therapeutic use)
- Female
- Humans
- Injections
(adverse effects)
- Iontophoresis
- Male
- Methylprednisolone
(administration & dosage, therapeutic use)
- Middle Aged
- Prospective Studies
- Treatment Outcome
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