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HLA B-27 subtypes in Turkish patients with spondyloarthropathy and healthy controls.

Abstract
The frequency and the distribution of HLA-B27 subtypes in spondylarthropathy (SpA) patients and controls were investigated in a sample Turkish population. B27 subtyping was performed by PCR-SSP method in two groups: 49 unrelated HLA-B27 positive Turkish patients with the diagnosis of SpA according to the European Spondyloarthropathy Study Group Criteria, and 55 HLA-B27 positive healthy controls. The frequency of HLA-B*27 was 2.6% in the Turkish population, and B*2705 was the predominant allele among patients with SpA. The difference was mainly between male patients and male controls The proportion of B*2705 among B27-positive patients and controls was significantly different (P=0.02). Our study supports other reports from different populations which showed that B*2705 and B*2702 were more frequent in Caucasian patients with SpA.
AuthorsFatma Savran Oguz, Lale Ocal, Ali Sarper Diler, Hilmi Ozkul, Faruk Asicioglu, Esen Kasapoglu, Gokay Bozkurt, Meral Konice, Mahmut Carin
JournalDisease markers (Dis Markers) Vol. 20 Issue 6 Pg. 309-12 ( 2004) ISSN: 0278-0240 [Print] United States
PMID15665390 (Publication Type: Journal Article)
Chemical References
  • HLA-B27 Antigen
  • DNA
Topics
  • Adult
  • Alleles
  • Case-Control Studies
  • DNA (metabolism)
  • Female
  • Genotype
  • HLA-B27 Antigen (genetics)
  • Humans
  • Male
  • Middle Aged
  • Polymorphism, Single-Stranded Conformational
  • Spondylitis, Ankylosing (genetics)
  • Turkey

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