Abstract |
The frequency and the distribution of HLA-B27 subtypes in spondylarthropathy (SpA) patients and controls were investigated in a sample Turkish population. B27 subtyping was performed by PCR-SSP method in two groups: 49 unrelated HLA-B27 positive Turkish patients with the diagnosis of SpA according to the European Spondyloarthropathy Study Group Criteria, and 55 HLA-B27 positive healthy controls. The frequency of HLA-B*27 was 2.6% in the Turkish population, and B*2705 was the predominant allele among patients with SpA. The difference was mainly between male patients and male controls The proportion of B*2705 among B27-positive patients and controls was significantly different (P=0.02). Our study supports other reports from different populations which showed that B*2705 and B*2702 were more frequent in Caucasian patients with SpA.
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Authors | Fatma Savran Oguz, Lale Ocal, Ali Sarper Diler, Hilmi Ozkul, Faruk Asicioglu, Esen Kasapoglu, Gokay Bozkurt, Meral Konice, Mahmut Carin |
Journal | Disease markers
(Dis Markers)
Vol. 20
Issue 6
Pg. 309-12
( 2004)
ISSN: 0278-0240 [Print] United States |
PMID | 15665390
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adult
- Alleles
- Case-Control Studies
- DNA
(metabolism)
- Female
- Genotype
- HLA-B27 Antigen
(genetics)
- Humans
- Male
- Middle Aged
- Polymorphism, Single-Stranded Conformational
- Spondylitis, Ankylosing
(genetics)
- Turkey
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