Abstract | AIM: To study the degrees of influence of changing side ester chains at position C20 of camptothecin on the anti- tumor activity of the molecules. METHODS: RESULTS: Both in vitro and in vivo anti- tumor activity studies for these esters were conducted and the data demonstrated positive results, that is, these esters were active against the tested tumor lines. CONCLUSION: Alkenyl esters 3 and 4 showed strong anti- tumor activity in vitro against 14 different cancer cell lines. Ester 3 was active against human breast carcinoma in mice and the toxicity of the agent was not observed in mice during the treatment, implying that this agent is effective for treatment with low toxicity.
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Authors | Zhi-Song Cao, John Mendoza, Albert Dejesus, Beppino Giovanella |
Journal | Acta pharmacologica Sinica
(Acta Pharmacol Sin)
Vol. 26
Issue 2
Pg. 235-41
(Feb 2005)
ISSN: 1671-4083 [Print] United States |
PMID | 15663905
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antineoplastic Agents, Phytogenic
- Esters
- rubitecan
- Camptothecin
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Topics |
- Animals
- Antineoplastic Agents, Phytogenic
(chemistry, pharmacology)
- Breast Neoplasms
(pathology)
- Camptothecin
(analogs & derivatives, chemical synthesis, chemistry, pharmacology)
- Cell Line, Tumor
(drug effects)
- Esters
(chemistry)
- Humans
- Inhibitory Concentration 50
- Mice
- Molecular Structure
- Neoplasm Transplantation
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