Differential expression of Hyaluronic Acid Binding Protein 1 (HABP1)/P32/C1QBP during progression of epidermal carcinoma.

Abstract	Our laboratory has characterized a novel cell surface glycoprotein, Hyaluronic Acid Binding Protein 1 (HABP1), interacting specifically with hyaluronan (HA) and regulating HA-mediated cellular event. The involvement of HA in different stages of carcinoma is well documented. In the present communication, the expression profile of HABP1 was investigated from initiation to progression of epidermal carcinoma in mice, induced by benzo[a]pyrene (B[a]P) exposure. During tumor initiation, HABP1 accumulated in inflammatory subsquamous tissue and with progression, the protein, was also seen to overexpress in papillomatic and acanthotic tissue. With the onset of metastasis, HABP1 overexpression was confined to metastatic islands, while it disappeared gradually from the surrounding mass. Such expression profiles in metastasized tissue were supported by decreased levels of HABP1, both at protein and transcript levels. These observations taken together suggest that the changes in HABP1 level coincide with specific stages of tumor progression, that lead to disruption of its interaction with HA, implying a role in the regulation of tumor metastasis.
Authors	Ilora Ghosh, Anindya Roy Chowdhury, Moganty R Rajeswari, Kasturi Datta
Journal	Molecular and cellular biochemistry (Mol Cell Biochem) Vol. 267 Issue 1-2 Pg. 133-9 (Dec 2004) ISSN: 0300-8177 [Print] Netherlands
PMID	15663194 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	C1qbp protein, mouse Carcinogens Hyaluronan Receptors Mitochondrial Proteins Benzo(a)pyrene Hyaluronic Acid
Topics	Animals Benzo(a)pyrene Carcinogens Carcinoma (chemically induced, genetics, metabolism, pathology) Disease Progression Gene Expression Profiling Gene Expression Regulation, Neoplastic Hyaluronan Receptors (genetics, metabolism) Hyaluronic Acid (metabolism) Immunohistochemistry Mice Mitochondrial Proteins Neoplasm Metastasis Neoplasms, Experimental (chemically induced, metabolism, pathology) Papilloma (chemically induced, genetics, metabolism, pathology) Protein Binding Rats Reverse Transcriptase Polymerase Chain Reaction Time Factors

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