Electrocardiographic alterations during treatment of mucocutaneous leishmaniasis with meglumine antimoniate and allopurinol.

Abstract

The electrocardiographic (ECG) changes in Bolivian patients with mucocutaneous leishmaniasis, treated with meglumine antimoniate and allopurinol, were evaluated. Electric changes due to the antimonial compound appeared in 45% of the patients, and consisted of repolarization alteration, principally affecting the T wave and the S-T segment. The changes disappeared within 2 months following the end of the antimonial treatment. In patients with associated Chagas disease and leishmaniasis, antimonial therapy did not aggravate the ECG changes characteristic of Chagasic cardiopathy.

• Authors: G Antezana, R Zeballos, C Mendoza, P Lyevre, L Valda, F Cardenas, I Noriega, H Ugarte, J P Dedet
• Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene (Trans R Soc Trop Med Hyg) 1992 Jan-Feb Vol. 86 Issue 1 Pg. 31-3 ISSN: 0035-9203 [Print] England
• PMID: 1566297 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antiprotozoal Agents
• Organometallic Compounds
• Allopurinol
• Meglumine
• Meglumine Antimoniate

Topics

• Adolescent
• Adult
• Allopurinol (therapeutic use)
• Antiprotozoal Agents (therapeutic use)
• Chagas Cardiomyopathy (physiopathology)
• Chagas Disease (complications)
• Electrocardiography (drug effects)
• Female
• Humans
• Leishmaniasis, Mucocutaneous (complications, drug therapy, physiopathology)
• Male
• Meglumine (therapeutic use)
• Meglumine Antimoniate
• Middle Aged
• Organometallic Compounds (therapeutic use)