Chaperones and slow death--a recipe for tumor immunotherapy.

Abstract

In an exciting recent paper Richard Vile and coworkers describe a novel approach to tumor immunotherapy based on the killing of a population of normal cells within an inflammatory environment. This approach builds on recent studies showing that the molecular chaperone Hsp70 can act at multiple stages during tumor antigen presentation to enhance the generation of CD8(+) T lymphocyte-mediated immunity and lead to regression of primary and metastatic tumors.

• Authors: Stuart K Calderwood
• Journal: Trends in biotechnology (Trends Biotechnol) Vol. 23 Issue 2 Pg. 57-9 (Feb 2005) ISSN: 0167-7799 [Print] England
• PMID: 15661338 (Publication Type: Journal Article, Review)

Chemical References

• HSP70 Heat-Shock Proteins
• Molecular Chaperones

Topics

• Animals
• Autoimmunity
• CD8-Positive T-Lymphocytes (immunology)
• Cell Death (immunology)
• HSP70 Heat-Shock Proteins (immunology)
• Humans
• Immunotherapy
• Melanocytes (immunology)
• Melanoma (immunology, therapy)
• Molecular Chaperones (immunology)
• Neoplasms (immunology, pathology, therapy)