Camurati-Engelmann disease: failure of response to bisphosphonates: report of two cases.

Abstract

Camurati-Engelmann disease is a rare bone disorder characterized by cortical thickening of the diaphysis of tubular bones, with sparing of the epiphysis. It has variable degrees of penetrance and expression, but may be very disabling for the affected individuals who manifest the painful symptoms. The authors report on two women with typical presentation of severe Camurati-Engelmann disease whose treatment with bisphosphonates failed to add any improvement beyond that elicited by corticosteroids alone.

• Authors: Glaucio R W Castro, Simone Appenzeller, João Francisco Marques-Neto, Manoel B Bértolo, Adil M Samara, Ibsen Coimbra
• Journal: Clinical rheumatology (Clin Rheumatol) Vol. 24 Issue 4 Pg. 398-401 (Aug 2005) ISSN: 0770-3198 [Print] Germany
• PMID: 15660289 (Publication Type: Case Reports, Journal Article)

Chemical References

• Diphosphonates

Topics

• Adult
• Bone Density (physiology)
• Camurati-Engelmann Syndrome (diagnosis, drug therapy)
• Densitometry
• Diphosphonates (administration & dosage)
• Dose-Response Relationship, Drug
• Drug Administration Schedule
• Female
• Follow-Up Studies
• Humans
• Rare Diseases
• Severity of Illness Index
• Treatment Failure