Obesity is considered a
chronic disease requiring treatment. The effect of
sibutramine combined with hypocaloric diet and exercise on
body weight, body fat mass,
lipids,
glycemic control, insulin secretion and
insulin resistance was evaluated in a randomized, controlled, open-label study. A total of 44 obese type 2 diabetic patients (aged 45.2+/-5.2 years, BMI 33.62+/-2.2 kg/m(2)) and 49 obese nondiabetic subjects (aged 41.9+/-5.7 years, BMI 34.3+/-2.6 kg/m(2)) were treated with
sibutramine for 3 months. Moreover, 39 age-matched obese type 2 diabetic patients and 41 obese nondiabetic subjects only on hypocaloric diet and exercise served as control groups. Insulin secretion was estimated during intravenous
glucose tolerance test;
insulin resistance was assessed by the HOMA index. There was a significant reduction in
body weight in both
sibutramine-treated diabetic patients (7.1%) and nondiabetic subjects (9.1%), accompanied by a significant reduction in body fat mass. HbA1c decreased significantly in the diabetic patients after
sibutramine treatment. There was a significant improvement of
lipid parameters in the two groups.
Insulin resistance decreased by 21.9% in the
sibutramine-treated diabetic patients and by 38.5% in the nondiabetic group.
Weight loss was accompanied by an increase of 43.8% in first phase insulin secretion in the
sibutramine-treated diabetic group; in the treated nondiabetic subjects there was a decrease in first and second phase insulin secretion and the area under the curve for total insulin secretion. In conclusion,
sibutramine leads to a significant reduction in
body weight, body fat mass and waist and hip circumferences; it improves
insulin sensitivity, insulin secretion, glycaemic control and
lipid parameters in both diabetic and nondiabetic obese subjects.