Abstract | OBJECTIVE: STUDY DESIGN: Double-blind, prospective randomized clinical trial. ANIMALS: Sixty client-owned dogs. METHODS: Dogs with surgical orthopedic disorders were randomly separated into 2 groups: 30 dogs were administered 0.2 mg/kg meloxicam intravenously (IV) immediately before induction and 30 dogs were administered 2 mg/kg ketoprofen IV, 30 minutes before the end of surgery. Pain was assessed with a visual analog scale (VAS) and a cumulative pain score (CPS) preoperatively and at 30 minutes, 1, 2, 3, 4, 6, 8, and 24 hours after extubation. Selected serum biochemical variables were measured before and 24 hours after surgery and, buccal mucosal bleeding time (BMBT) and whole blood clotting time (WBCT) were measured before and 8 hours after surgery. Dogs were anesthetized with propofol and maintained on halothane in oxygen. Any complications were documented for 7 days after surgery. Results were compared between the 2 groups for significant differences in VAS scores (2-sample t-test) and in CPS (Wilcoxon's 2-sample test). Moreover, results were analyzed for significant differences in area under the curve (AUC) for VAS (2-sample t-test) and CPS (Wilcoxon's 2-sample test) among groups. To assess the effects of treatments on biochemical and coagulation functions, pre- and postoperative mean values of BMBT and WBCT were compared within both treatment groups (paired t-tests) and between both groups (2-sample t-test). RESULTS: CONCLUSIONS: CLINICAL RELEVANCE:
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Authors | Aymeric J Deneuche, Cédric Dufayet, Laurent Goby, Pascal Fayolle, Christophe Desbois |
Journal | Veterinary surgery : VS
(Vet Surg)
2004 Nov-Dec
Vol. 33
Issue 6
Pg. 650-60
ISSN: 0161-3499 [Print] United States |
PMID | 15659022
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Analgesics, Non-Narcotic
- Anti-Inflammatory Agents, Non-Steroidal
- Thiazines
- Thiazoles
- Ketoprofen
- Meloxicam
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Topics |
- Analgesia
(methods, veterinary)
- Analgesics, Non-Narcotic
(administration & dosage)
- Animals
- Anti-Inflammatory Agents, Non-Steroidal
(administration & dosage)
- Dog Diseases
(surgery)
- Dogs
(physiology)
- Double-Blind Method
- Infusions, Intravenous
(veterinary)
- Ketoprofen
(administration & dosage)
- Meloxicam
- Orthopedic Procedures
(methods, veterinary)
- Pain Measurement
(veterinary)
- Pain, Postoperative
(prevention & control, veterinary)
- Prospective Studies
- Thiazines
(administration & dosage)
- Thiazoles
(administration & dosage)
- Treatment Outcome
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