Near-total parathyroidectomy is beneficial for patients with secondary and tertiary hyperparathyroidism.

Abstract

BACKGROUND:

Despite several options for the extent of parathyroidectomy in secondary and tertiary hyperparathyroidism, <5% of patients are referred for surgical procedures. The purpose of this study was to identify beneficial outcomes of near-total parathyroidectomy (NTPTX) in this population.

METHODS:

NTPTX (a vascularized parathyroid remnant is left in situ, and cryopreservation is performed) was completed in 142 patients with secondary (n = 93 patients) and tertiary (n = 49 patients) hyperparathyroidism, and was guided by intraoperative intact PTH (IOPTH).

RESULTS:

One hundred thirty-six of 142 patients (96%) remain cured at a mean follow-up time of 23 +/- 26 months. Six patients had missed mediastinal (n = 4 patients) or cervical (n = 2 patients) parathyroid glands. No patient required re-resection of a cervical parathyroid remnant. One patient had hypoparathyroidism and underwent autografting with cryopreserved tissue. NTPTX reduced parathyroid mass (4526 +/- 4515 mg to 77 +/- 56 mg) and IOPTH (1171 +/- 1252 pg/mL to 101 +/- 127 pg/mL). Fatigue and musculoskeletal pain resolved promptly after operation. Patients with tertiary hyperparathyroidism experienced an improvement in bone density of 3.6% per year. NTPTX achieved full healing of extremity ulcers without amputations or perioperative death in 22 patients with calciphylaxis.

CONCLUSIONS:

NTPTX effectively treats secondary and tertiary hyperparathyroidism in >95% patients. IOPTH monitoring and cryopreservation are valuable procedural adjuncts. Limb salvage in calciphylaxis, symptomatic relief, and improved bone density are substantial benefits to recommend this procedure to patients with renal hyperparathyroidism.

• Authors: Mira Milas, Collin J Weber
• Journal: Surgery (Surgery) Vol. 136 Issue 6 Pg. 1252-60 (Dec 2004) ISSN: 0039-6060 [Print] United States
• PMID: 15657584 (Publication Type: Journal Article)

Chemical References

• Parathyroid Hormone

Topics

• Adult
• Female
• Humans
• Hyperparathyroidism (blood, diagnosis, surgery)
• Male
• Middle Aged
• Parathyroid Hormone (blood)
• Parathyroidectomy (methods)
• Treatment Outcome