Endometrial adenocarcinoma without prior hormone replacement in a diabetic patient with gonadal dysgenesis.

Abstract

Patients with dysgenetic gonads and Turner syndrome are unlikely to develop endometrial carcinoma unless they have received unopposed estrogen replacement therapy. This case describes a 54-year-old woman with Turner syndrome and primary amenorrhea who developed adenocarcinoma of the endometrium without having received hormone replacement. Vaginal bleeding, a pelvic mass, and sepsis were the presenting symptoms. The patient also had diabetes mellitus and hypothyroidism. Polyglandular endocrine patterns are known to occur with a high frequency in these patients. The woman's chromosome studies revealed a modified 46,X,i(Xq) (isochromosome X). This is the first report of an isochromosome X patient to develop endometrial cancer without receiving estrogen replacement. The etiology of this rare case may be an increased propensity for patients with X-chromosome deletions to develop neoplasms in general, or extragonadal estrogen production.

• Authors: K Kratzert-Adams, M D Adelson, S Z Badawy, C K Stein, L Gordon
• Journal: Obstetrics and gynecology (Obstet Gynecol) Vol. 79 Issue 5 ( Pt 2) Pg. 849-53 (May 1992) ISSN: 0029-7844 [Print] United States
• PMID: 1565385 (Publication Type: Case Reports, Journal Article)

Topics

• Adenocarcinoma (complications)
• Diabetes Mellitus, Type 2 (complications)
• Endometrial Neoplasms (complications)
• Estrogen Replacement Therapy (adverse effects)
• Female
• Humans
• Middle Aged
• Risk Factors
• Turner Syndrome (complications)