Bioactive constituents of Artemisia monosperma.

Abstract

During a study on the chemistry and biological activity of Kuwaiti plants, new metabolites including 4,6-dihydroxy-3-[3'-methyl-2'-butenyl]-5-[4''-hydroxy-3''-methyl-2''-butenyl]-cinnamic acid (1), the 3R,8R stereoisomer of the C17 polyacetylene dehydrofalcarindiol (2) and a C10 polyacetylene glucoside (3) were characterised by spectroscopic means. Additionally, the previously characterised natural products 1,3R,8R-trihydroxydec-9-en-4,6-yne (4), spathulenol (5) and eriodyctiol-7-methyl ether (6) were also isolated. Compounds 2, 3, and 4 were evaluated for their ability to inhibit the enzyme 12-lipoxygenase and 3 and 4 showed moderate activity at 30 microg/ml. Compound 2 was evaluated against a panel of colorectal and breast cancer cell lines and IC50 values ranged from 5.8 to 37.6 microg/ml. Against a panel of fast-growing mycobacteria and a standard ATCC strain of Staphylococcus aureus, compound 6 exhibited minimum inhibitory concentrations in the range of 64-128 microg/ml.

• Authors: Michael Stavri, Christopher H J Ford, Franz Bucar, Bernhard Streit, Michael L Hall, R Thomas Williamson, K T Mathew, Simon Gibbons
• Journal: Phytochemistry (Phytochemistry) Vol. 66 Issue 2 Pg. 233-9 (Jan 2005) ISSN: 0031-9422 [Print] England
• PMID: 15652580 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Bacterial Agents
• Antineoplastic Agents, Phytogenic
• Lipoxygenase Inhibitors
• Plant Extracts

Topics

• Anti-Bacterial Agents (chemistry, pharmacology)
• Antineoplastic Agents, Phytogenic (chemistry, pharmacology)
• Artemisia (chemistry)
• Cell Line, Tumor
• Humans
• Lipoxygenase Inhibitors
• Magnetic Resonance Spectroscopy
• Microbial Sensitivity Tests
• Molecular Structure
• Mycobacterium (drug effects)
• Plant Extracts (chemistry, pharmacology)
• Staphylococcus aureus (drug effects)