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Influence of vitamin C on cadmium absorption and distribution in rats.

Abstract
The purpose of the present study was to evaluate the effect of a dietary vitamin C supplement on cadmium absorption and distribution in an animal model. An aqueous solution of cadmium chloride (labelled with cadmium-109) was given by gavage to male Wistar rats for 28 days at a daily dose corresponding to 10 mg Cd/kg diet (1.0-1.2 mg Cd/kg b.w.). The animals assigned to groups 1 and 2 (45 animals per group) received a standard laboratory diet LSM, and tap water or tap water supplemented with ascorbic acid (1.5 mg/l), respectively. The radioactivity of the samples was measured using a liquid scintillation counter (tissue samples) and a gas-flow automatic counter (ashed carcasses). The fractional uptake of cadmium-109 in the carcass and organs was evaluated within 32 days after treatment by dividing the cadmium-109 activity in the whole sample by the total activity of cadmium-109 administered for 28 days. Results were compared using AUC (areas under the concentration time curve) values. The vitamin C supplement decreased the carcass cadmium burden and the cadmium content in the liver, kidneys, testicles and muscles; the highest decreases were found in the testicles, the lowest ones in the muscles. In addition, the rats supplemented with vitamin C revealed an improved body weight gain during the experimental period.
AuthorsAndrzej Grosicki
JournalJournal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) (J Trace Elem Med Biol) Vol. 18 Issue 2 Pg. 183-7 ( 2004) ISSN: 0946-672X [Print] Germany
PMID15646266 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Cadmium
  • Cadmium Chloride
  • Ascorbic Acid
Topics
  • Animals
  • Ascorbic Acid (pharmacology)
  • Body Weight
  • Cadmium (metabolism)
  • Cadmium Chloride (metabolism)
  • Cadmium Poisoning (prevention & control)
  • Evaluation Studies as Topic
  • Intestinal Absorption (drug effects)
  • Male
  • Organ Size
  • Rats
  • Tissue Distribution

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