RESULTS: Seventeen patients (nine in the
ramipril group and eight in the
verapamil group) completed the study. The mean age of the patients, duration of illness, 24 hours urinary excretion of
protein, mean arterial pressure, serum
creatinine,
cholesterol and
albumin were similar in both the groups at time of randomization. The 24 hours urinary
protein excretion decreased from 6319.44 +/- 1971.70 mg/day to 1852.44 +/- 1813.74 mg/day in patients receiving
ramipril and from 5332.87 +/- 1947.47 mg /day to 2759.37 +/- 1929.6 mg/day in patients treated with
verapamil after 12 months. There was no statistically significant difference in the reduction of
proteinuria between the two groups. However, reduction in
proteinuria was statistically significant from 2nd month onwards in
Ramipril group and reduction was sustained throughout the study period. Reduction in mean arterial pressure was better achieved in
Ramipril groups. The change in the serum
potassium,
creatinine,
cholesterol and
albumin were similar in either group of patients.
Cough (2),
hypotension (1) and reversible rise in serum
creatinine (1) were observed with
ramipril and no side effect was noted with
verapamil.
CONCLUSION: