Reaching recommended lipid and blood pressure targets with amlodipine/atorvastatin combination in patients with coronary heart disease.

Abstract

The effects of combined atorvastatin and amlodipine on blood pressure (BP) and low-density lipoprotein (LDL) cholesterol levels were investigated in 134 patients with documented coronary heart disease treated for 1 year. BP at baseline was 128 +/- 15/79 +/- 9 mm Hg and was controlled by the treating physician; no calcium channel blockers were allowed. Baseline means for plasma cholesterol were 6.4 +/- 1.1 mmol/L (147 +/- 39 mg/dl), triglycerides 2.0 +/- 0.9 mmol/L (177 +/- 88 mg/dl), LDL cholesterol 4.4 +/- 1.0 mmol/L (170 +/- 39 mg/dl), and high-density lipoprotein cholesterol 1.2 +/- 0.3 mmol/L (46 +/- 12 mg/dl). Patients were all given atorvastatin 10 mg, then increased to 80 mg if the LDL cholesterol was <2.5 mmol/L (100 mg/dl). At 3 months, patients were randomized to amlodipine 10 mg or placebo. Plasma LDL cholesterol was decreased by 50%, and the LDL cholesterol target of <2.5 mmol/L was achieved in 81% of the patients. BP targets were achieved in 69% of the atorvastatin + placebo group, versus 96% in the atorvastatin + amlodipine group (p = 0.0002). With use of combination atorvastatin + amlodipine at doses ranging from 10 to 80 mg and 5 to 10 mg, respectively, recommended therapeutic goals were reached in most select subjects with coronary artery disease who were concomitantly receiving aspirin and antihypertensive therapy.

• Authors: Jean-Francois Dorval, Todd Anderson, Jean Buithieu, Sammy Chan, Stuart Hutchison, Thao Huynh, Jean Jobin, Eva Lonn, Paul Poirier, Lawrence Title, Ann Walling, Thang Tran, Ghyslain Boudreau, Francois Charbonneau, Jacques Genest
• Journal: The American journal of cardiology (Am J Cardiol) Vol. 95 Issue 2 Pg. 249-53 (Jan 15 2005) ISSN: 0002-9149 [Print] United States
• PMID: 15642561 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Antihypertensive Agents
• Cholesterol, HDL
• Cholesterol, LDL
• Heptanoic Acids
• Hydroxymethylglutaryl-CoA Reductase Inhibitors
• Pyrroles
• Triglycerides
• Amlodipine
• Cholesterol
• Atorvastatin

Topics

• Amlodipine (administration & dosage)
• Antihypertensive Agents (administration & dosage)
• Atorvastatin
• Blood Pressure
• Canada
• Cholesterol (blood)
• Cholesterol, HDL (blood)
• Cholesterol, LDL (blood)
• Coronary Artery Disease (blood, drug therapy, physiopathology)
• Drug Administration Schedule
• Drug Therapy, Combination
• Female
• Heptanoic Acids (administration & dosage)
• Humans
• Hydroxymethylglutaryl-CoA Reductase Inhibitors (administration & dosage)
• Male
• Middle Aged
• Pyrroles (administration & dosage)
• Treatment Outcome
• Triglycerides (blood)