Abstract | BACKGROUND: CASE REPORT: An alert 18-month-old presented to hospital 40 minutes after ingesting up to 6 mg (0.5 mg/kg) of pimozide. Vital signs: BP 91/62 mmHg, HR 130/min, RR 26/min, temperature 97.2 degrees F (36.2 degrees C). She received gastric lavage and activated charcoal. One hour later, her QTc interval was 420 msec, HR 150. She remained asymptomatic until 12 hours post-ingestion, when she developed drooling, tongue thrusting and drowsiness. BP was 75/40, HR 150, QTc 440 msec. BP increased to 95/50 after a bolus of normal saline. Her dystonia subsided over the next 12 hours without treatment. Drowsiness and tachycardia persisted until 40 hours post-ingestion. QTc interval at this time was 370 msec. Patient recovered without sequelae. CONCLUSION:
Pimozide overdose in children may be associated with delayed onset of symptoms, including dystonia.
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Authors | Robert D Gair, Marjorie S Friesen, Debra A Kent |
Journal | Journal of toxicology. Clinical toxicology
(J Toxicol Clin Toxicol)
Vol. 42
Issue 7
Pg. 977-81
( 2004)
ISSN: 0731-3810 [Print] United States |
PMID | 15641643
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Dopamine Antagonists
- Pimozide
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Topics |
- Adolescent
- Dopamine Antagonists
(poisoning)
- Drug Overdose
- Dystonia
(chemically induced)
- Electrocardiography
(drug effects)
- Hemodynamics
(drug effects)
- Humans
- Hypotension
(chemically induced)
- Male
- Pimozide
(poisoning)
- Salivation
(drug effects)
- Sleep Stages
(drug effects)
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