Abstract | OBJECTIVE: METHODS: Of 134 specimens from lung lobectomy, 105 were primary lung carcinomas including 76 non- small cell carcinomas (NSCLCs), 28 small cell lung cancers (SCLCs) and 1 complex carcinoma (SCLC and SCC), and 29 were metastatic carcinomas. Expression of TTF-1 was detected by immunohistochemistry. The expression level of TTF-1 was graded as, +:6% to 25% of tumor cells positive, ++:26% to 50%, +++:51% to 75%, and ++++:> 76%. RESULTS: The positive nuclear immunoreactivity of TTF-1 was identified in 23 of 28 SCLCs (82.1%), but none in squamous cell cancer (SCC) (P < 0.001). The positive expression rate of TTF-1 in lung adenocarcinomas (ACs) was 73.8% (31/42). There was no correlation between TTF-1 expression and ACs differentiation or ACs subtypes (P > 0.05). All but one (thyroid follicular carcinoma) metastatic ACs were TTF-1-positive. Mesenchymal component and lymphoid or inflammatory cells were consistently TTF-1-negative. CONCLUSION: A significant difference of TTF-1 expression may assist in distinguishing SCLC from SCC, lymphoma or inflammatory lesions. Owing to its restrictive expression in lung tissue, TTF-1 might be used to differentiate primary from metastatic adenocarcinoma of the lung.
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Authors | Dong-mei Lin, Shuang-mei Zou, Ning Lü, Peng Wen, Xiu-yun Liu, Zu-gen He |
Journal | Zhonghua zhong liu za zhi [Chinese journal of oncology]
(Zhonghua Zhong Liu Za Zhi)
Vol. 26
Issue 10
Pg. 615-7
(Oct 2004)
ISSN: 0253-3766 [Print] China |
PMID | 15634524
(Publication Type: Journal Article)
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Chemical References |
- NKX2-1 protein, human
- Nuclear Proteins
- Thyroid Nuclear Factor 1
- Transcription Factors
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Topics |
- Adenocarcinoma
(diagnosis, metabolism)
- Breast Neoplasms
(pathology)
- Carcinoma, Non-Small-Cell Lung
(diagnosis, metabolism)
- Colorectal Neoplasms
(pathology)
- Diagnosis, Differential
- Humans
- Lung Neoplasms
(diagnosis, metabolism, secondary)
- Nuclear Proteins
(biosynthesis)
- Thyroid Nuclear Factor 1
- Transcription Factors
(biosynthesis)
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