Abstract | AIM: METHODS: One hundred and twelve patients with histologically proven NAFLD were studied. RESULTS: The histological stage of NAFLD correlated with several clinical and biochemical variables, the extent of hepatic fibrosis and the markers of liver fibrosis were relatively strong associated. The best cutoff values to detect NASH were assessed by using receiver operating characteristic analysis: type VI collagen 7S domain > or =5.0 ng/mL, hyaluronic acid > or =43 ng/mL. Both markers had a high positive predictive value: type VI collagen 7S domain, 86% and hyaluronic acid, 92%. Diagnostic accuracies of these markers were evaluated to detect severe fibrosis. Both markers showed high negative predictive values: type VI collagen 7S domain (> or =5.0 ng/mL), 84% and hyaluronic acid (> or =50 ng/mL), 78%, and were significantly and independently associated with the presence of NASH or severe fibrosis by logistic regression analysis. CONCLUSION:
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Authors | Hiroshi Sakugawa, Tomofumi Nakayoshi, Kasen Kobashigawa, Tsuyoshi Yamashiro, Tatsuji Maeshiro, Satoru Miyagi, Joji Shiroma, Akiyo Toyama, Tomokuni Nakayoshi, Fukunori Kinjo, Atsushi Saito |
Journal | World journal of gastroenterology
(World J Gastroenterol)
Vol. 11
Issue 2
Pg. 255-9
(Jan 14 2005)
ISSN: 1007-9327 [Print] United States |
PMID | 15633226
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- Collagen Type IV
- Glycated Hemoglobin A
- Immunoglobulin A
- Immunoglobulin G
- Immunoglobulin M
- Hyaluronic Acid
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Topics |
- Adult
- Aged
- Biomarkers
(blood)
- Collagen Type IV
(blood)
- Fatty Liver
(blood, pathology)
- Female
- Glycated Hemoglobin
(analysis)
- Humans
- Hyaluronic Acid
(blood)
- Immunoglobulin A
(blood)
- Immunoglobulin G
(blood)
- Immunoglobulin M
(blood)
- Liver Cirrhosis
(blood, pathology)
- Liver Function Tests
- Male
- Middle Aged
- ROC Curve
- Reproducibility of Results
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