Abstract | OBJECTIVES: METHODS: RESULTS: Treatment with AR-C or L-NIL reduced the plasma levels of amylase and the volume of supplementary fluids and improved the histological score (all P < 0.05). In animals with acute pancreatitis, plasma arginine levels were reduced (P < 0.05), while citrulline and ornithine levels increased (P < 0.05), consistent with increased nitric oxide production. Treatment with AR-C ameliorated the reduced arginine level. CONCLUSIONS: Treatment with AR-C or L-NIL, commencing 2 hours after the induction of acute pancreatitis, has significant and beneficial effects in experimental acute pancreatitis in Australian possums.
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Authors | Per Sandstrom, Mark E Brooke-Smith, Anthony C Thomas, Marlene B Grivell, Gino T P Saccone, James Toouli, Joar Svanvik |
Journal | Pancreas
(Pancreas)
Vol. 30
Issue 1
Pg. e10-5
(Jan 2005)
ISSN: 1536-4828 [Electronic] United States |
PMID | 15632690
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- AR C102222AA
- Amino Acids
- Enzyme Inhibitors
- N(6)-(1-iminoethyl)lysine
- Quinazolines
- Nitric Oxide Synthase Type II
- Lipase
- Amylases
- Lysine
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Topics |
- Acute Disease
- Amino Acids
(blood)
- Amylases
(blood)
- Animals
- Central Venous Pressure
- Disease Models, Animal
- Enzyme Inhibitors
(pharmacology)
- Female
- Hematocrit
- Lipase
(blood)
- Lysine
(analogs & derivatives, pharmacology)
- Male
- Nitric Oxide Synthase Type II
(antagonists & inhibitors, metabolism)
- Pancreatitis
(drug therapy, metabolism, pathology)
- Quinazolines
(pharmacology)
- Trichosurus
- Water-Electrolyte Balance
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