[Effects of Eupolyphaga Sinensis Walker on erythrocyte's CR1 activity and anti-cardiolipin antibody level in rats with stagnation of blood].

Abstract

AIM:

To study the effect of Eupolyphaga Sinensis Walker(ESW) on red blood cell immune adherence (RCIA) and serum anticardiolipin antibody level in rat model of Yin-deficiency Huo-excess with chronic blood stasis.

METHODS:

The model was made by i.m. injection of dexamethasone (0.5 mg/kg) and adrenaline (0.84 mg/kg). The serum anti-cardiolipin antibodies (ACA) ACA-IgG, ACA-IgA and ACA-IgM and the plasma D-dimmer levels were measured by using enzyme-linked immunosorbent assay (ELISA). The body and organ weight of the rats were measured.

RESULTS:

For rats of Yin-deficiency Huo-excess, rosette rates of red blood cell C3b receptors (RBC-C3b RR) and red blood cell cancer (RBC-CaR) decreased, the serum ACA-IgG, ACA-IgA, ACA-IgM and the plasma D-dimmer levels markedly increased, body weight and the weight of spleen and thymus all decreased. ESW (5 mg/kg, 10 mg/kg) increased RBC-C3bRR and RBC-CaR, reduced serum ACA-IgG, ACA-IgA, ACA-IgM and plasma D-dimmer levels, and increased spleen weight of the rats.

CONCLUSION:

ESW can boost the immune function in rats of Yin-deficiency Huo-excess with chronic blood stasis.

• Authors: Yao-Fang Yang, Sai-Qian Wang, Mei-Jia Feng, Ai-Hua Ning, Chang-Hui Huang
• Journal: Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology (Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi) Vol. 21 Issue 1 Pg. 53-6 (Jan 2005) ISSN: 1007-8738 [Print] China
• PMID: 15629084 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antibodies
• Cardiolipins
• Fibrin Fibrinogen Degradation Products
• Receptors, Complement 3b
• fibrin fragment D

Topics

• Animals
• Antibodies (immunology, metabolism)
• Body Weight (immunology)
• Cardiolipins (immunology)
• Cockroaches (immunology)
• Erythrocytes (immunology)
• Female
• Fibrin Fibrinogen Degradation Products (metabolism)
• Male
• Organ Size (immunology)
• Rats
• Receptors, Complement 3b (metabolism)
• Yin Deficiency (immunology, pathology)