Stimulation of bone formation by zoledronic acid in particle-induced osteolysis.

Abstract

We investigated the effect of a single subcutaneous dose of zoledronic acid on particle-induced osteolysis and observed excessive regional new bone formation. We utilized the murine calvarial osteolysis model and polyethylene particles in C57BL/J6 mice. Twenty-eight mice were used, seven per group. Specimens were stained with Giemsa dye. The osteoid tissue area was determined. Bone thickness was measured as an indicator of bone growth. Net bone growth was significantly increased in animals with zoledronic acid treatment: 0.02 mm(2)+/-0.03 mm(2) in animals with particle implantation only (group 2), 0.25 mm(2)+/-0.08 mm(2) with particle implantation and zoledronic acid treatment directly after surgery (group 3; p=0.0018), and 0.21 mm(2)+/-0.11 mm(2) with particle implantation and zoledronic acid treatment on the fourth postoperative day (group 4; p=0.0042). The mean bone thickness was 0.2 mm+/-0.04 mm (range 0.17 mm-0.31 mm) in group 1 (sham controls) and 0.16 mm+/-0.02 mm (range 0.14 mm-0.19 mm) in group 2, 0.31 mm+/-0.04 mm (range 0.28 mm-0.39 mm) in group 3, and 0.29 mm+/-0.02 mm (range 0.28 mm-0.34 mm) in group 4. Student's t-test revealed a statistically significant difference between groups 2 and 3 (p=0.00042), and groups 2 and 4 (p=0.0019). In conclusion, our observational study suggests that zoledronic acid may stimulate bone apposition locally in the process of particle-induced osteolysis.

• Authors: Christian Wedemeyer, Fabian von Knoch, Andreas Pingsmann, Gero Hilken, Christoph Sprecher, Guido Saxler, Frank Henschke, Franz Löer, Marius von Knoch
• Journal: Biomaterials (Biomaterials) Vol. 26 Issue 17 Pg. 3719-25 (Jun 2005) ISSN: 0142-9612 [Print] Netherlands
• PMID: 15621262 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Diphosphonates
• Imidazoles
• Polyethylenes
• ultra-high molecular weight polyethylene
• Zoledronic Acid

Topics

• Animals
• Diphosphonates (administration & dosage)
• Foreign-Body Reaction (chemically induced, pathology, prevention & control)
• Imidazoles (administration & dosage)
• Mice
• Mice, Inbred C57BL
• Osteogenesis (drug effects)
• Osteolysis (chemically induced, pathology, prevention & control)
• Particle Size
• Polyethylenes (adverse effects)
• Prosthesis Failure
• Prosthesis-Related Infections (chemically induced, prevention & control)
• Skull (drug effects, pathology)
• Treatment Outcome
• Zoledronic Acid