Abstract | BACKGROUND: METHODS: Eighteen renal transplant patients with cyclosporine-induced gingival hyperplasia were included in the study. All patients received azithromycin with a dose of 500 mg/d for 3 consecutive days. Changes in gingival hyperplasia were evaluated by measuring the gingival sulcus depth to the cementum-enamel junction of every tooth in each of the four quadrants on days 0, 7, 30, 90, 180. Gum biopsies were obtained on days 0 and 30; the degree of inflammation was classified as "mild," "intermediate," and "severe". RESULTS:
Gingival hyperplasia was reduced in all treated patients throughout the study. The degree of improvement was more significant between 0 to 7 and 7 to 30 days than at other times (respectively, P < .0001 and P < .002). Histopathologically, eight patients had severe and one patient moderate chronic inflammation at the beginning of therapy. Three other biopsies were reported as papilloma, mucosal hyperplasia, and normal gingival tissue biopsy. CONCLUSIONS:
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Authors | B Tokgöz, H I Sari, O Yildiz, S Aslan, M Sipahioğlu, T Okten, O Oymak, C Utaş |
Journal | Transplantation proceedings
(Transplant Proc)
Vol. 36
Issue 9
Pg. 2699-702
(Nov 2004)
ISSN: 0041-1345 [Print] United States |
PMID | 15621128
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Anti-Bacterial Agents
- Immunosuppressive Agents
- Azithromycin
- Cyclosporine
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Topics |
- Adult
- Anti-Bacterial Agents
(therapeutic use)
- Azithromycin
(therapeutic use)
- Biopsy
- Cyclosporine
(adverse effects)
- Female
- Gingival Hyperplasia
(chemically induced, drug therapy, pathology)
- Humans
- Immunosuppressive Agents
(adverse effects)
- Kidney Transplantation
(immunology, pathology)
- Male
- Middle Aged
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