Angiolipoma of the buccal mucosa: a possible role of mast cell-derived VEGF in its enhanced vascularity.

Abstract

A case of angiolipoma occurring in the buccal mucosa of a 69-year-old male is described. The patient had noticed a painless mass in his buccal mucosa for 2 years. The surgically removed tumor, measuring 9 mm in diameter, was mainly located in the submucosal layer with focal expansion into the muscle layer. Histologically, the tumor was well-demarcated and composed of proliferations of mature fat cells and fibrous connective tissue containing many small blood vessels, which were evenly distributed. There was diffuse infiltration of a large number of mast cells, which were immunopositive for vascular endothelial growth factor (VEGF) especially around blood vessels, suggesting that VEGF produced by mast cells in angiolipomas plays an important role in the vascular proliferation in this particular tumor.

• Authors: Hiroko Ida-Yonemochi, Wael Swelam, Chikara Saito, Takashi Saku
• Journal: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (J Oral Pathol Med) Vol. 34 Issue 1 Pg. 59-61 (Jan 2005) ISSN: 0904-2512 [Print] Denmark
• PMID: 15610409 (Publication Type: Case Reports, Journal Article)

Chemical References

• Vascular Endothelial Growth Factor A

Topics

• Aged
• Angiolipoma (blood supply)
• Humans
• Male
• Mast Cells (metabolism)
• Mouth Mucosa (blood supply)
• Mouth Neoplasms (blood supply)
• Vascular Endothelial Growth Factor A (metabolism)