Abstract | BACKGROUND: METHODS: RESULTS:
Pyridoxamine treatment resulted in significantly lower (by approximately 50%) levels of urinary glycolate and oxalate excretion compared to untreated hyperoxaluric animals. This was accompanied by a significant reduction in calcium oxalate crystal formation in papillary and medullary areas of the kidney. CONCLUSION:
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Authors | Sergei V Chetyrkin, Daniel Kim, John M Belmont, Jon I Scheinman, Billy G Hudson, Paul A Voziyan |
Journal | Kidney international
(Kidney Int)
Vol. 67
Issue 1
Pg. 53-60
(Jan 2005)
ISSN: 0085-2538 [Print] United States |
PMID | 15610227
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Glyoxylates
- Calcium Oxalate
- Pyridoxamine
- glyoxylic acid
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Topics |
- Animals
- Calcium Oxalate
(metabolism, urine)
- Crystallization
- Disease Models, Animal
- Glyoxylates
(metabolism)
- Humans
- Hyperoxaluria, Primary
(drug therapy, metabolism, urine)
- Kidney
(drug effects, metabolism, pathology)
- Male
- Pyridoxamine
(therapeutic use)
- Rats
- Rats, Sprague-Dawley
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