Ehlers-Danlos syndrome is a rare disorder, comprising a group of related inherited disorders of connective tissue, resulting from underlying abnormalities in the synthesis and metabolism of
collagen. This proposal is specifically concerned with
Ehlers-Danlos syndrome classic type (formerly Types I-III), which is characterized by
joint hypermobility and susceptibility to injury/
arthritis, skin and vascular problems (including easy bruising,
bleeding,
varicose veins and poor tissue healing), cardiac
mitral valve prolapse, musculo-skeletal problems (
myopathy,
myalgia, spinal
scoliosis,
osteoporosis), and susceptibility to
periodontitis. No treatment is currently available for this disorder. The novel aspect of this proposal is based on: (i) increasing scientific evidence that nutrition may be a major factor in the pathogenesis of many disorders once thought to result from defective genes alone; (ii) the recognition that many of the symptoms associated with
Ehlers-Danlos syndrome are also characteristic of
nutritional deficiencies; (iii) the synergistic action within the body of appropriate combinations of nutritional supplements in promoting normal tissue function. We therefore hypothesize that the symptoms associated with
Ehlers-Danlos syndrome may be successfully alleviated using a specific (and potentially synergistic) combination of nutritional supplements, comprising
calcium,
carnitine,
coenzyme Q(10),
glucosamine,
magnesium, methyl sulphonyl methane,
pycnogenol,
silica,
vitamin C, and
vitamin K, at dosages which have previously been demonstrated to be effective against the above symptoms in other disorders.