Abstract | BACKGROUND: OBJECTIVE: METHODS: A 64-year-old woman presented for evaluation and treatment of recurrent tumors in her face and extremities. Despite repeated invasive surgical removal of these lesions, recurrence of fast-growing giant keratoacanthomas developed in the pretibial region of her left lower leg. Owing to recurrence after conventional surgery and the tumor size, a novel treatment method using ablative Er:YAG laser combined with topical 5-fluorouracil was performed. RESULTS: After four treatments with excellent patient compliance, histologic analysis of punch biopsies revealed tumor-free ulcerations. Complete epithelization was obtained after 9 weeks. Six months after the treatment, no recurrence was observed. CONCLUSION:
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Authors | Jens J Thiele, Mirjana Ziemer, Silke Fuchs, Peter Elsner |
Journal | Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
(Dermatol Surg)
Vol. 30
Issue 12 Pt 2
Pg. 1556-60
(Dec 2004)
ISSN: 1076-0512 [Print] United States |
PMID | 15606840
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Antimetabolites, Antineoplastic
- Fluorouracil
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Topics |
- Administration, Cutaneous
- Antimetabolites, Antineoplastic
(administration & dosage, therapeutic use)
- Combined Modality Therapy
- Diagnosis, Differential
- Drug Administration Schedule
- Female
- Fluorouracil
(administration & dosage, therapeutic use)
- Humans
- Keratoacanthoma
(diagnosis, drug therapy, pathology, surgery)
- Laser Therapy
- Leg
- Middle Aged
- Recurrence
- Skin Diseases
(diagnosis, drug therapy, pathology, surgery)
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