Abstract | OBJECTIVE: DESIGN: Prospective, randomized trial. SETTING: Academic research center. ANIMAL(S): Female Naval Medical Research Institute mice (n = 100). INTERVENTION(S): Sixty minutes of CO2 pneumoperitoneum with 0%, 3%, 6%, 9%, or 12% oxygen; induction of adhesions by the creation of standardized peritoneal lesions during laparoscopy. MAIN OUTCOME MEASURE(S): Adhesions were quantitatively and qualitatively scored after 7 days during laparotomy to determine [1] the effect of 60 minutes of CO2 pneumoperitoneum with 0%, 3%, 6%, 9%, or 12% oxygen on adhesion formation, and [2] the effect of duration of CO2 pneumoperitoneum and insufflation pressure on adhesion formation with the addition of 0%, 3%, and 12% oxygen. RESULT(S): CONCLUSION(S): This study confirms that adhesion formation is decreased with the addition of 3% oxygen to the CO2 pneumoperitoneum. The addition of higher oxygen concentrations, however, is deleterious. Adhesions always increase with time and duration of the pneumoperitoneum.
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Authors | Osama Ali Elkelani, Maria Mercedes Binda, Carlos Roger Molinas, Philippe Robert Koninckx |
Journal | Fertility and sterility
(Fertil Steril)
Vol. 82
Issue 6
Pg. 1616-22
(Dec 2004)
ISSN: 0015-0282 [Print] United States |
PMID | 15589868
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Animals
- Carbon Dioxide
- Dose-Response Relationship, Drug
- Female
- Laparoscopy
- Mice
- Mice, Inbred Strains
- Oxygen
(administration & dosage, pharmacology)
- Peritoneal Diseases
(etiology, pathology, prevention & control)
- Pneumoperitoneum, Artificial
- Random Allocation
- Time Factors
- Tissue Adhesions
(etiology, pathology, prevention & control)
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