Abstract | OBJECTIVE: To determine the effect of urinary versus recombinant FSH on platelet function and hemostatic variables in women undergoing controlled ovarian hyperstimulation cycles. DESIGN: Randomized clinical study. SETTING: Major university-based infertility and in vitro fertilization unit and hemostasis laboratory. PATIENT(S): Ten healthy women (in vitro study), and 24 women undergoing routine controlled ovarian hyperstimulation cycles (in vivo study), randomly assigned to receive either urinary (u-FSH) or recombinant gonadotropin (r-FSH). INTERVENTION(S): In vitro study: effect of preincubation of plasma with u-FSH or r-FSH, in the presence or absence of estradiol, on platelet function and coagulation parameters. In vivo study: Changes in platelet function and coagulation parameters after treatment with u-FSH or r-FSH during controlled ovarian hyperstimulation cycles. MAIN OUTCOME MEASURE(S): RESULT(S): In vitro study: Platelet aggregation and ATP release were significantly inhibited by u-FSH relative to r-FSH in both the presence and absence of estradiol (P=.047). In vivo study: Platelet function was significantly inhibited after treatment with u-FSH (P=.05) but not with r-FSH. In both studies, small changes of minor clinical significance were noted in activated protein C resistance and free protein S levels. CONCLUSION(S): The different platelet response to u-FSH and r-FSH may have clinical implications in selected patients, especially those at risk of thromboembolic complications, in decisions regarding the appropriate medication for controlled ovarian hyperstimulation cycles.
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Authors | Jacob Bar, Raoul Orvieto, Judith Lahav, Moshe Hod, Boris Kaplan, Benjamin Fisch |
Journal | Fertility and sterility
(Fertil Steril)
Vol. 82
Issue 6
Pg. 1564-9
(Dec 2004)
ISSN: 0015-0282 [Print] United States |
PMID | 15589861
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Follicle Stimulating Hormone, Human
- Protein S
- Recombinant Proteins
- Estradiol
- Menotropins
- Adenosine Triphosphate
- Follicle Stimulating Hormone
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Topics |
- Activated Protein C Resistance
- Adenosine Triphosphate
(antagonists & inhibitors)
- Adult
- Blood Platelets
(drug effects)
- Drug Therapy, Combination
- Estradiol
(therapeutic use)
- Female
- Follicle Stimulating Hormone
(therapeutic use, urine)
- Follicle Stimulating Hormone, Human
(therapeutic use)
- Hemostasis
(drug effects)
- Humans
- Infertility
(blood, drug therapy, physiopathology)
- Menotropins
(therapeutic use)
- Ovulation Induction
- Platelet Aggregation
(drug effects)
- Protein S
(metabolism)
- Recombinant Proteins
(therapeutic use)
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