Photodynamic therapy of subfoveal and juxtafoveal choroidal neovascularization in ocular histoplasmosis syndrome: a retrospective case series.

Abstract

PURPOSE:

To evaluate the safety and effect on visual acuity of photodynamic therapy (PDT) with verteporfin in patients with subfoveal and juxtafoveal choroidal neovascular membranes from ocular histoplasmosis syndrome (OHS).

METHODS:

Retrospective case series. The visual outcome of 11 patients with subfoveal (n = 6) and juxtafoveal (n = 5) choroidal neovascularization treated with PDT was reviewed. At 1 to 3 months of follow-up, retreatment with PDT was performed if angiography showed leakage.

RESULTS:

Within the subfoveal group, 3 patients (50%) had improved vision (two or more lines better than initial vision), 2 patients (33.3%) had no change in vision (within 1 line), and 1 (16.7%) lost four lines of vision. At last follow-up, 3 patients (50%) had vision between 20/20 and 20/40 compared with only 1 patient (16.6%) at the initial visit. Mean follow-up was 13.7 months. Within the juxtafoveal group, 3 patients (60%) had improved vision, 1 patient (20%) had no change in vision, and 1 patient (20%) lost nine lines of vision. At last follow-up, 3 of 5 patients (60%) had vision between 20/20 and 20/40 compared with 2 patients (40%) at the initial visit. Mean follow-up was 10.2 months. No significant adverse effects were reported.

CONCLUSION:

PDT is a safe and promising option for patients with OHS with choroidal neovascularization that is subfoveal or juxtafoveal.

• Authors: Judy C Liu, H Culver Boldt, James C Folk, Karen M Gehrs
• Journal: Retina (Philadelphia, Pa.) (Retina) Vol. 24 Issue 6 Pg. 863-70 (Dec 2004) ISSN: 0275-004X [Print] United States
• PMID: 15579982 (Publication Type: Journal Article)

Chemical References

• Photosensitizing Agents
• Porphyrins
• Verteporfin

Topics

• Adolescent
• Adult
• Choroidal Neovascularization (drug therapy, etiology)
• Eye Infections, Fungal (complications, drug therapy)
• Female
• Fluorescein Angiography
• Follow-Up Studies
• Fovea Centralis
• Histoplasmosis (complications, drug therapy)
• Humans
• Male
• Middle Aged
• Photochemotherapy
• Photosensitizing Agents (adverse effects, therapeutic use)
• Porphyrins (adverse effects, therapeutic use)
• Retrospective Studies
• Safety
• Syndrome
• Verteporfin
• Visual Acuity