[Efficiency of voriconazole in fungal keratitis caused by candida albicans].

Abstract

CASE REPORT:

A 70-year-old woman, with a history of diabetes and persistent corneal ulceration, developed a severe keratitis caused by Candida albicans. It evolved rapidly to corneal perforation in spite of treatment with topical amphotericin B and oral itraconazole. An amniotic membrane transplant was performed as an emergency, associated with systemic administration of voriconazole. The infection was solved successfully, although the patient needed a penetrating keratoplasty to restore the corneal transparency.

DISCUSSION:

Fungal keratitis caused by Candida albicans usually follows an aggressive course and may simulate a bacterial aetiology. Voriconazole is a new antifungal drug that appears to be very effective in the management of ocular infections caused by many filamentous and levaduriform fungi.

• Authors: J M Granados, N Puerto, M J Carrilero
• Journal: Archivos de la Sociedad Espanola de Oftalmologia (Arch Soc Esp Oftalmol) Vol. 79 Issue 11 Pg. 565-8 (Nov 2004) ISSN: 0365-6691 [Print] Spain
• Vernacular Title: Eficacia del voriconazol en queratitis fúngica por cándida albicans.
• PMID: 15578288 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Antifungal Agents
• Pyrimidines
• Triazoles
• Voriconazole

Topics

• Aged
• Antifungal Agents (therapeutic use)
• Candidiasis (drug therapy)
• Female
• Humans
• Keratitis (drug therapy, microbiology)
• Pyrimidines (therapeutic use)
• Triazoles (therapeutic use)
• Voriconazole