The decrease of particle-induced osteolysis after a single dose of bisphosphonate.

Abstract

The most common cause of implant failure in joint replacement is aseptic loosening due to particle-induced osteolysis. Bisphosphonates have been shown to be effective against particle-induced osteolysis when administered daily. We investigated the effect of a single subcutaneous dose of a more potent third generation bisphosphonate on particle-induced osteolysis. We utilized the murine calvaria osteolysis model in C57BL/J6 mice. Bone resorption was measured as resorption within the midline suture using Giemsa staining. Twenty-eight mice were used, seven per group. Seven animals were treated with a single dose of zoledronic acid (ZA) directly after surgery and seven animals were treated four days postoperatively. For statistical analysis one-way ANOVA and a Student's t-test were used. Bone resorption was 0.26+/-0.09 mm(2) in animals with particle implantation, 0.14+/-0.05 mm(2) in animals with particle implantation and ZA treatment directly after surgery (p = 0.0047), and 0.15+/-0.05 mm(2) in animals with particle implantation and ZA treatment on the fourth postoperative day (p = 0.006). In conclusion, particle-induced bone resorption was markedly decreased by a single s.c. dose of a third generation bisphosphonate. This important new finding holds great promise, because single dose treatment of particle-induced osteolysis may reduce side effects compared to repeated application of bisphosphonates.

• Authors: Marius von Knoch, Christian Wedemeyer, Andreas Pingsmann, Fabian von Knoch, Gero Hilken, Christoph Sprecher, Frank Henschke, Bertram Barden, Franz Löer
• Journal: Biomaterials (Biomaterials) Vol. 26 Issue 14 Pg. 1803-8 (May 2005) ISSN: 0142-9612 [Print] Netherlands
• PMID: 15576154 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biocompatible Materials
• Diphosphonates
• Imidazoles
• Zoledronic Acid
• Polyethylene

Topics

• Animals
• Biocompatible Materials (adverse effects)
• Diphosphonates (administration & dosage)
• Female
• Foreign-Body Reaction (drug therapy, etiology, pathology)
• Imidazoles (administration & dosage)
• Injections, Subcutaneous
• Male
• Materials Testing
• Mice
• Mice, Inbred C57BL
• Osteolysis (drug therapy, etiology, pathology, prevention & control)
• Particle Size
• Polyethylene (adverse effects)
• Severity of Illness Index
• Treatment Outcome
• Zoledronic Acid