Abstract | OBJECTIVE:
Biliary atresia is a neonatal obstructive cholangiopathy characterized by a destructive, obliterative process affecting both the intrahepatic and extrahepatic ducts of the biliary tree that uniquely presents in the first months of life. The consequence of progressive inflammatory and sclerotic reaction is the development of obstructive jaundice. To determine the proinflammatory cytokine profile in children with biliary atresia, we measured circulating levels of interleukin (IL)-1beta, IL-6, tumor necrosis factor-alpha and IL-8. METHODS: RESULTS: CONCLUSIONS:
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Authors | Valerio Nobili, Matilde Marcellini, Luigi Giovannelli, Elia Girolami, Flaminia Muratori, Germana Giannone, Rita Devito, Fabrizio De Benedetti |
Journal | Journal of pediatric gastroenterology and nutrition
(J Pediatr Gastroenterol Nutr)
Vol. 39
Issue 5
Pg. 540-4
(Nov 2004)
ISSN: 0277-2116 [Print] United States |
PMID | 15572896
(Publication Type: Journal Article)
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Chemical References |
- Interleukin-1
- Interleukin-6
- Interleukin-8
- Tumor Necrosis Factor-alpha
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Topics |
- Biliary Atresia
(blood, immunology, pathology)
- Case-Control Studies
- Chronic Disease
- Female
- Humans
- Infant
- Interleukin-1
(blood)
- Interleukin-6
(blood)
- Interleukin-8
(blood)
- Liver
(enzymology, immunology, pathology)
- Liver Diseases
(blood, immunology, pathology)
- Male
- Tumor Necrosis Factor-alpha
(metabolism)
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