Abstract | OBJECTIVE: METHOD: RESULT: The frequency of II genotype and I allele were significantly higher in the OSAHS accompanied hypertension patients than those in the healthy controls (chi2=9.88, chi2=16.13, P<0.01, respectively) and in the normotensive OSAHS patients (chi2=5.67, P<0.05, chi2=8.61, P<0.01). The frequency of II genotype and I allele had no significantly different between the normotensive OSAHS patients and the healthy controls (P>0.05). The serum level of angiotensin II was significantly higher in both OSAHS patients with and without hypertension than that in the healthy control (t=3.66, t=3.23, respectively P<0.01). Whereas the serum level of angiotensin II have no significantly different in the OSAHS patients with and without hypertension (P>0.05). CONCLUSION: These results indicate that the higher frequency of ACE gene I allele and genotype are closely associated with OSAHS patients accompanied hypertension. It is one of the important risk factors for the genesis of hypertension in OSAHS. The activity of rennin-angiotension system is higher in the OSAHS may have contribute to OSAHS-induced hypertension.
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Authors | Yanzhong Li, Wanrong Zhang, Tingchu Wang, Hongxia Lu, Xin Wang, Yan Wang |
Journal | Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
(Lin Chuang Er Bi Yan Hou Ke Za Zhi)
Vol. 18
Issue 8
Pg. 456-9
(Aug 2004)
China |
PMID | 15571307
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Angiotensin II
- Peptidyl-Dipeptidase A
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Topics |
- Adult
- Angiotensin II
(blood)
- Female
- Humans
- Hypertension
(complications)
- Male
- Middle Aged
- Peptidyl-Dipeptidase A
(genetics)
- Polymorphism, Genetic
- Sleep Apnea, Obstructive
(complications, genetics)
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