Abstract | BACKGROUND: METHODS AND RESULTS: CONCLUSIONS:
Simvastatin combined with losartan improves endothelial function and reduces inflammatory markers to a greater extent than monotherapy with either drug in hypercholesterolemic, hypertensive patients.
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Authors | Kwang Kon Koh, Michael J Quon, Seung Hwan Han, Wook-Jin Chung, Jeong Yeal Ahn, Yiel-Hea Seo, Moon Ho Kang, Tae Hoon Ahn, In Suck Choi, Eak Kyun Shin |
Journal | Circulation
(Circulation)
Vol. 110
Issue 24
Pg. 3687-92
(Dec 14 2004)
ISSN: 1524-4539 [Electronic] United States |
PMID | 15569835
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Adiponectin
- Angiotensin II Type 1 Receptor Blockers
- Biomarkers
- CCL2 protein, human
- Chemokine CCL2
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
- Intercellular Signaling Peptides and Proteins
- Lipids
- Malondialdehyde
- C-Reactive Protein
- Simvastatin
- Losartan
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Topics |
- Adiponectin
- Angiotensin II Type 1 Receptor Blockers
(therapeutic use)
- Biomarkers
(blood)
- Blood Pressure
(drug effects)
- C-Reactive Protein
(analysis)
- Chemokine CCL2
(blood)
- Cross-Over Studies
- Double-Blind Method
- Drug Synergism
- Drug Therapy, Combination
- Female
- Humans
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
(therapeutic use)
- Hypercholesterolemia
(complications, drug therapy, metabolism, physiopathology)
- Hypertension
(complications, drug therapy, metabolism, physiopathology)
- Insulin Resistance
- Intercellular Signaling Peptides and Proteins
(blood)
- Lipids
(blood)
- Losartan
(therapeutic use)
- Male
- Malondialdehyde
(blood)
- Middle Aged
- Simvastatin
(therapeutic use)
- Vasodilation
(drug effects)
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