Plasma lipid peroxides: relationships to cardiovascular risk factors and prevalent cardiovascular disease.

Abstract

BACKGROUND:

The epidemiology of plasma lipid peroxides, which may play a role in atherogenesis, has not been well defined.

AIM:

To study the relationships of plasma lipid peroxides to cardiovascular risk factors in a random population sample.

DESIGN:

Random, age- and sex-stratified population sample.

METHODS:

We studied 739 men and women aged 25-74 years. Lipid peroxides were assayed by the thiobarbituric acid (TBA) assay for malondialdehyde (MDA) in stored plasma samples.

RESULTS:

Lipid peroxide levels increased with age. In men, lipid peroxides were significantly associated with smoking habit. Lipid peroxides correlated with non-fasting serum triglycerides (r = 0.33; p < 0.0001) in both sexes. Weaker associations were observed for cholesterol, high-density lipoprotein cholesterol (inversely), body mass index, fibrinogen and white cell count; as well as an inverse association with serum vitamin C in men.

DISCUSSION:

These findings clarify the relationships of plasma lipid peroxides to cardiovascular risk factors; and are consistent with the hypothesis that lipid peroxidation may be one mechanism through which several risk factors may promote cardiovascular disease.

• Authors: A G Rumley, M Woodward, A Rumley, J Rumley, G D O Lowe
• Journal: QJM : monthly journal of the Association of Physicians (QJM) Vol. 97 Issue 12 Pg. 809-16 (Dec 2004) ISSN: 1460-2725 [Print] England
• PMID: 15569813 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Lipid Peroxides

Topics

• Adult
• Age Distribution
• Aged
• Cardiovascular Diseases (blood, epidemiology)
• Cross-Sectional Studies
• Female
• Humans
• Lipid Peroxides (blood)
• Male
• Middle Aged
• Regression Analysis
• Risk Factors
• Scotland (epidemiology)
• Sex Distribution