Abstract | STUDY OBJECTIVES: DESIGN: Prospective, randomized, double-blind study. SETTING: Large referral hospital. PATIENTS: INTERVENTIONS: A standard general anesthetic was administered. In all cases surgery was performed via a Pfannenstiel incision. On completion of the surgery, a multi-orifice, 20-gauge epidural catheter was placed above the fascia such that the tip was sited at the point that demarcated 50% of the length of the surgical wound. Thereafter, the catheter was connected to an electronic patient-controlled analgesia (PCA) device programmed to deliver 9 mL of drug, with a lockout time of 60 minutes and no basal infusion. Patients were randomized to receive PCA with ropivacaine 0.1% (Group 0.1) or ropivacaine 0.2% (Group 0.2). During the first 6 postoperative hours, a co-investigator administered "rescue" morphine (2 mg IV). Thereafter, "rescue" meperidine 1 mg/kg was administered on patient request. MEASUREMENTS AND MAIN RESULTS: The number of attempts to activate the PCA device and actual PCA instillations during the 24 hour study period were similar between the groups. The number of 2 mg "rescue" morphine dosages administered was 4.3 +/- 1.7 versus 4.4 +/- 2.5 for the Group 0.1 and Group 0.2, respectively. For Group 0.1 and Group 0.2, the total dose of "rescue" morphine administered during the first 6 postoperative hours was 8.7 mg +/- 3.6 versus 9.1 mg +/- 5, respectively. "Rescue" meperidine administration during the subsequent 18 hours was similar between the groups. Throughout the study period, pain scores were similar between the groups. CONCLUSION:
|
Authors | Edna Zohar, Arie Shapiro, Alex Phillipov, David Hoppenstein, Zvi Klein, Brian Fredman |
Journal | Journal of clinical anesthesia
(J Clin Anesth)
Vol. 16
Issue 6
Pg. 399-404
(Sep 2004)
ISSN: 0952-8180 [Print] United States |
PMID | 15567641
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
|
Chemical References |
- Amides
- Analgesics, Opioid
- Anesthetics, Local
- Morphine
- Ropivacaine
|
Topics |
- Amides
(administration & dosage, therapeutic use)
- Analgesia, Patient-Controlled
- Analgesics, Opioid
(administration & dosage, therapeutic use)
- Anesthetics, Local
(administration & dosage, therapeutic use)
- Dose-Response Relationship, Drug
- Double-Blind Method
- Female
- Humans
- Hysterectomy
- Instillation, Drug
- Middle Aged
- Morphine
(administration & dosage, therapeutic use)
- Ovariectomy
- Pain Measurement
(drug effects)
- Pain, Postoperative
(drug therapy)
- Prospective Studies
- Ropivacaine
|