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Anticonvulsant effects of carbenoxolone in genetically epilepsy prone rats (GEPRs).

Abstract
Carbenoxolone (CBX), the succinyl ester of glycyrrhetinic acid, is an inhibitor of gap junctional intercellular communication. Systemic administration of CBX was able to decrease the seizure severity score and to increase the latency time of seizure onset in genetically epilepsy prone rats (GEPRs). In particular, intravenous or intraperitoneal administration of carbenoxolone (5-30 mg/kg) produced a dose-dependent and significant reduction in the clonic and tonic phases of the audiogenic seizures in GEPRs. The anticonvulsant doses were not associated with an impairment of motor coordination. The bilateral microinjection of CBX (0.001-0.50 microg/0.5 microl) into the inferior colliculi, the substantia nigra (pars reticulata or compacta) and the inferior olivary complex was able to reduce the seizure severity score in a dose-dependent manner. The anticonvulsant effects were longer lasting after focal microinjection than after systemic administration. No anticonvulsant effects were observed following focal bilateral microinjections of glycyrrhizin into the same brain areas where CBX was shown to be effective.
AuthorsPietro Gareri, Daniele Condorelli, Natale Belluardo, Emilio Russo, Antonella Loiacono, Vincenza Barresi, Angela Trovato-Salinaro, Angela Trovato-Salinato, Melita B Mirone, Guido Ferreri Ibbadu, Giovambattista De Sarro
JournalNeuropharmacology (Neuropharmacology) Vol. 47 Issue 8 Pg. 1205-16 (Dec 2004) ISSN: 0028-3908 [Print] England
PMID15567430 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Anticonvulsants
  • Connexins
  • connexin 36
  • Carbenoxolone
Topics
  • Animals
  • Anticonvulsants (therapeutic use)
  • Carbenoxolone (therapeutic use)
  • Connexins (biosynthesis)
  • Epilepsy (drug therapy, genetics, metabolism)
  • Female
  • Male
  • Rats
  • Rats, Sprague-Dawley

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