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Evaluation of in vitro and in vivo antitumor activity of BCNU-loaded PLGA wafer against 9L gliosarcoma.

Abstract
The purpose of the present study was to develop implantable BCNU-loaded poly(D,L-lactide-co-glycolide) (PLGA) wafer for the controlled release of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) and to evaluate its in vitro and in vivo antitumor activity. The release rate of BCNU from PLGA wafer increased with the increase of BCNU amount loaded and the release was continued until 7 days. In vitro and in vivo antitumor activity of BCNU-loaded PLGA wafer was investigated using in vitro cytotoxicity against 9L gliosarcoma cells and a subcutaneous (s.c.) solid tumor model of 9L gliosarcoma, respectively. The wafers containing BCNU showed more effective cytotoxicity than BCNU powder due to its short half-life and inhibited the proliferation of 9L gliosarcoma cells. BCNU-loaded PLGA wafer delayed the growth of the tumors significantly and increasing the dose of BCNU in the wafer resulted in a substantial regression of the tumor. These results of antitumor activity of BCNU-loaded PLGA wafer demonstrate the feasibility of the wafers for clinical application.
AuthorsJin Soo Lee, Tae Kun An, Gang Soo Chae, Je Kyo Jeong, Sun Hang Cho, Hai Bang Lee, Gilson Khang
JournalEuropean journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V (Eur J Pharm Biopharm) Vol. 59 Issue 1 Pg. 169-75 (Jan 2005) ISSN: 0939-6411 [Print] Netherlands
PMID15567315 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antineoplastic Agents
  • Polymers
  • Polylactic Acid-Polyglycolic Acid Copolymer
  • Polyglycolic Acid
  • Lactic Acid
  • Carmustine
Topics
  • Animals
  • Antineoplastic Agents (administration & dosage, pharmacokinetics)
  • Carmustine (administration & dosage, pharmacokinetics)
  • Cell Line, Tumor
  • Cell Survival (drug effects, physiology)
  • Drug Evaluation, Preclinical (methods)
  • Gliosarcoma (drug therapy, metabolism)
  • Lactic Acid (administration & dosage, pharmacokinetics)
  • Male
  • Polyglycolic Acid (administration & dosage, pharmacokinetics)
  • Polylactic Acid-Polyglycolic Acid Copolymer
  • Polymers (administration & dosage, pharmacokinetics)
  • Rats
  • Rats, Inbred F344

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