Abstract |
The aim of the present study was to compare viral kinetics between patients with chronic hepatitis C and persistently normal alanine aminotransferase (ALT) levels and those with elevated ALT levels. Kinetic parameters were derived from nonlinear, least square fitting of serum hepatitis C virus RNA quantifications collected from patients with chronic hepatitis C and persistently normal (n = 20) and elevated (n = 19) ALT levels before and during treatment with 180 mug pegylated interferon alpha-2a once weekly plus daily ribavirin. Patients with chronic hepatitis C and persistently normal ALT levels showed a trend to lower pretreatment infected cell loss (delta) (P = .13) but no differences in efficacy of blocking virus production (epsilon) and infected cell loss during treatment (mdelta) compared with patients with elevated ALT levels. Differences were significant for epsilon (P = .02) and delta (P = .04) when applying updated "healthy" levels for ALT (0.75 times and 0.63 times upper limit of normal for male and female patients, respectively). A significant reduction of the kinetic parameters epsilon, delta, and mdelta was observed in patients with elevated gamma-glutamyltranspeptidase (GGT) levels compared with patients with normal GGT levels (P = .02, P = .005, and P = .02, respectively). In conclusion, viral kinetics are similar in patients with chronic hepatitis C and persistently normal ALT levels and those with elevated ALT levels. However, in patients with elevated GGT levels, a major association with reduced efficacy of blocking virus production and lower infected cell loss was observed. These data show that virological response in patients with chronic hepatitis C is less associated with baseline ALT than with GGT levels.
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Authors | Bernd Kronenberger, Eva Herrmann, Florence Micol, Michael von Wagner, Stefan Zeuzem |
Journal | Hepatology (Baltimore, Md.)
(Hepatology)
Vol. 40
Issue 6
Pg. 1442-9
(Dec 2004)
ISSN: 0270-9139 [Print] United States |
PMID | 15565603
(Publication Type: Clinical Trial, Clinical Trial, Phase III, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antiviral Agents
- Interferon alpha-2
- Interferon-alpha
- Recombinant Proteins
- Polyethylene Glycols
- Ribavirin
- gamma-Glutamyltransferase
- Alanine Transaminase
- peginterferon alfa-2a
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Topics |
- Adult
- Aged
- Alanine Transaminase
(blood)
- Antiviral Agents
(administration & dosage)
- Drug Therapy, Combination
- Female
- Hepacivirus
(drug effects, growth & development)
- Hepatitis C, Chronic
(blood, drug therapy, virology)
- Humans
- Interferon alpha-2
- Interferon-alpha
(administration & dosage)
- Kinetics
- Male
- Middle Aged
- Polyethylene Glycols
(administration & dosage)
- Recombinant Proteins
- Ribavirin
(administration & dosage)
- gamma-Glutamyltransferase
(blood)
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