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The synthetic N-terminal peptide of human lactoferrin, hLF(1-11), is highly effective against experimental infection caused by multidrug-resistant Acinetobacter baumannii.

Abstract
The lactoferrin-derived peptide hLF(1-11), but not its control peptide, was highly effective against five multidrug-resistant Acinetobacter baumannii strains in vitro (3 to 4 log reduction) and against four of these strains in an experimental infection in mice (2 to 3 log reduction). Therefore, this peptide is a promising candidate as a novel agent against infections with multidrug-resistant A. baumannii.
AuthorsLenie Dijkshoorn, Carlo P J M Brouwer, Sylvia J P Bogaards, Alexandr Nemec, Peterhans J van den Broek, Peter H Nibbering
JournalAntimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 48 Issue 12 Pg. 4919-21 (Dec 2004) ISSN: 0066-4804 [Print] United States
PMID15561882 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Peptide Fragments
  • lactoferrin (1-11), human
  • Lactoferrin
Topics
  • Acinetobacter Infections (drug therapy, microbiology)
  • Acinetobacter baumannii (drug effects)
  • Amino Acid Sequence
  • Animals
  • Colony-Forming Units Assay
  • Dose-Response Relationship, Drug
  • Drug Resistance, Multiple, Bacterial
  • Lactoferrin
  • Male
  • Mice
  • Molecular Sequence Data
  • Peptide Fragments (therapeutic use)

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