Abstract |
The lactoferrin-derived peptide hLF(1-11), but not its control peptide, was highly effective against five multidrug-resistant Acinetobacter baumannii strains in vitro (3 to 4 log reduction) and against four of these strains in an experimental infection in mice (2 to 3 log reduction). Therefore, this peptide is a promising candidate as a novel agent against infections with multidrug-resistant A. baumannii.
|
Authors | Lenie Dijkshoorn, Carlo P J M Brouwer, Sylvia J P Bogaards, Alexandr Nemec, Peterhans J van den Broek, Peter H Nibbering |
Journal | Antimicrobial agents and chemotherapy
(Antimicrob Agents Chemother)
Vol. 48
Issue 12
Pg. 4919-21
(Dec 2004)
ISSN: 0066-4804 [Print] United States |
PMID | 15561882
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Peptide Fragments
- lactoferrin (1-11), human
- Lactoferrin
|
Topics |
- Acinetobacter Infections
(drug therapy, microbiology)
- Acinetobacter baumannii
(drug effects)
- Amino Acid Sequence
- Animals
- Colony-Forming Units Assay
- Dose-Response Relationship, Drug
- Drug Resistance, Multiple, Bacterial
- Lactoferrin
- Male
- Mice
- Molecular Sequence Data
- Peptide Fragments
(therapeutic use)
|