Abstract | OBJECTIVE: METHOD: We conducted a double-blind, placebo-controlled study of topiramate in 29 female subjects (response rate 93.5%) meeting SCID (Structured Clinical Interview for DSM-IV) criteria for borderline personality disorder. The subjects were randomly assigned in a 2:1 ratio to topiramate (N = 21, analysis based on N = 19) or placebo (N = 10). Treatment lasted 8 weeks (November 2003-January 2004). Primary outcome measures were self-reported changes on the anger subscales of the State-Trait Anger Expression Inventory (STAXI). RESULTS: Significant improvements on 4 subscales of the STAXI (state-anger, trait-anger, anger-out, anger-control) were observed in the topiramate-treated subjects after 8 weeks, in comparison with the placebo group. The difference in improvement in score between the 2 groups for state-anger, trait-anger, and anger-out ranged from 21% to 24%, and the difference for anger-control was -13%. As an exception, a difference of only 8.5% ( p < .2) was found on the anger-in subscale. Significantly greater weight loss was observed in the topiramate-treated group than in those treated with placebo (difference in weight loss between the 2 groups: 2.3 kg [5.1 lb] [3.2%]; 95% CI = 1.3% to 4.4%, p < .01). All patients tolerated topiramate well. CONCLUSIONS:
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Authors | Marius K Nickel, Cerstin Nickel, Ferdinand O Mitterlehner, Karin Tritt, Claas Lahmann, Peter K Leiberich, Wolfhardt K Rother, Thomas H Loew |
Journal | The Journal of clinical psychiatry
(J Clin Psychiatry)
Vol. 65
Issue 11
Pg. 1515-9
(Nov 2004)
ISSN: 0160-6689 [Print] United States |
PMID | 15554765
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Anticonvulsants
- Placebos
- Topiramate
- Fructose
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Topics |
- Adult
- Aggression
(drug effects, psychology)
- Anger
(drug effects)
- Anticonvulsants
(pharmacology, therapeutic use)
- Borderline Personality Disorder
(diagnosis, drug therapy, psychology)
- Double-Blind Method
- Female
- Fructose
(analogs & derivatives, pharmacology, therapeutic use)
- Humans
- Placebos
- Psychiatric Status Rating Scales
- Topiramate
- Treatment Outcome
- Weight Loss
(drug effects)
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