Abstract | OBJECTIVE: METHODS: One hundred patients with CHF were divided into 4 Syndrome Differentiation-type groups, their cardiac function parameters, ANP and thyroid hormones were determined and compared with those in the 23 subjects in the control group. RESULTS: In CHF patients with edema and blood stasis Syndrome type, the level of plasma ANP was significantly higher than that in the control group (P < 0.05); level of T3 was significantly lower than that in the control group and in CHF patients of other three (Xin-qi deficiency, Yin-deficiency and blood stasis) Syndrome groups (P < 0.01, P < 0.01, P < 0.05 and P < 0.01); levels of LVEF and mVcf were significantly lower than those in the other three Syndrome groups (all P < 0.01). Level of T4 in other three Syndrome groups significantly increased than that in the edema and blood stasis Syndrome type. A/E value showed a higher level in patients of all TCM type than that in the control (P < 0.01). Correlation analysis showed that T3 was positively correlated with LVEF and T4 (r = 0.200, P < 0.05, and r = 0.293, P < 0.01), and negatively correlated with ANP (r = -0.263, P < 0.01); T4 was negatively correlated with A/E (r = -0.226, P < 0.05). CONCLUSION: The lowering of T3 and T4 and increasing of ANP may be one of the important reasons for lowering of LVEF in CHF patients with edema and blood stasis Syndrome-type. The decrease of T4 may be one of the important reasons for elevation of A/E and aggravation of left ventricular diastolic dysfunction in CHF patients of all the 4 TCM Syndrome-types.
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Authors | Jie Zhou, Xiao-ling Gao, Bao-zhou Zhang, Shijun Huang, Landi Wang, Li Sheng, Dongjing Shi, Xiaoxia Yan, Ani Yang, Tenghui Huang, Yuqin Pei, Jinfan Chen, Xuan Cheng |
Journal | Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine
(Zhongguo Zhong Xi Yi Jie He Za Zhi)
Vol. 24
Issue 10
Pg. 872-5
(Oct 2004)
ISSN: 1003-5370 [Print] China |
PMID | 15553815
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Thyroid Hormones
- Triiodothyronine
- Atrial Natriuretic Factor
- Thyrotropin
- Thyroxine
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Topics |
- Adult
- Aged
- Atrial Natriuretic Factor
(metabolism)
- Diagnosis, Differential
- Female
- Heart Failure
(blood, physiopathology)
- Humans
- Male
- Medicine, Chinese Traditional
- Middle Aged
- Myocardial Contraction
- Stroke Volume
(physiology)
- Thyroid Hormones
(blood)
- Thyrotropin
(blood)
- Thyroxine
(blood)
- Triiodothyronine
(blood)
- Ventricular Dysfunction, Left
(physiopathology)
- Ventricular Function, Left
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