[Case report--Complete response of liver metastasis of rectal cancer after combination chemotherapy of CPT-11 + UFT-E].

Abstract

A 54-year-old man underwent abdominoperineal resection for rectal cancer. Adjuvant chemotherapy was not performed because of stage I cancer. Nine months after the operation, solitary liver metastasis, and elevated CEA and CA19-9, were found during the postoperative work-up. A combination chemotherapy of CPT-11 and UFT-E was performed before scheduled liver resection. 150 mg/m2 of CPT-11 was administered on days 1 and 15. 375 mg/m2/day of UFT-E was divided in half and administered on days 3-7, 10-14, 17-21, and 24-28 as one course of treatment. This regimen was repeated every 5 weeks. The patient had a grade 2 diarrhea and nentropenia during the treatment. Bowel obstruction was also observed after 5 courses of treatment, which required hospitalization. In addition, the liver metastasis had disappeared. There was no evidence of recurrence after 8 months of chemotherapy. It was suggested that CPT-11+UFT-E combination chemotherapy was effective for advanced colorectal cancer.

• Authors: Taishi Hata, Masataka Ikeda, Masakazu Ikenaga, Iwao Seshimo, Osamu Takayama, Hiroki Fukunaga, Masayoshi Yasui, Hirofumi Yamamoto, Masayuki Ohue, Mitsugu Sekimoto, Morito Monden
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 31 Issue 11 Pg. 1702-4 (Oct 2004) ISSN: 0385-0684 [Print] Japan
• PMID: 15553688 (Publication Type: Case Reports, Journal Article)

Chemical References

• Tegafur
• Uracil
• Irinotecan
• Camptothecin

Topics

• Antineoplastic Combined Chemotherapy Protocols (administration & dosage)
• Camptothecin (administration & dosage, analogs & derivatives)
• Drug Administration Schedule
• Humans
• Irinotecan
• Liver Neoplasms (drug therapy, secondary)
• Male
• Middle Aged
• Rectal Neoplasms (pathology, surgery)
• Tegafur (administration & dosage)
• Uracil (administration & dosage)