Effect of zolpidem on brain injury and diaschisis as detected by 99mTc HMPAO brain SPECT in humans.

The study investigates the effect of zolpidem (CAS 82626-48-0) on brain injuries and cerebellar diaschisis. Four patients with varied brain injuries, three of them with cerebellar diaschisis, were imaged by 99mTc HMPAO Brain SPECT before and after application of zolpidem. The baseline SPECT before zolpidem showed poor tracer uptake in brain injury areas and cerebellar diaschisis. After zolpidem, cerebral perfusion through brain injury areas improved substantially in three patients and the cerebellar diaschisis was reversed. Observations point to a GABA based phenomenon that occurs in brain injury and diaschisis that is reversible by zolpidem.
AuthorsRalf P Clauss, Wally H Nel
JournalArzneimittel-Forschung (Arzneimittelforschung) Vol. 54 Issue 10 Pg. 641-6 ( 2004) ISSN: 0004-4172 [Print] Germany
PMID15553102 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Hypnotics and Sedatives
  • Pyridines
  • Radiopharmaceuticals
  • Technetium Tc 99m Exametazime
  • Zolpidem
  • Adult
  • Brain Injuries (diagnostic imaging, drug therapy, metabolism)
  • Cerebellar Diseases (diagnostic imaging, drug therapy, metabolism)
  • Cerebrovascular Circulation (drug effects)
  • Child, Preschool
  • Diabetes Mellitus (physiopathology)
  • Humans
  • Hypnotics and Sedatives (therapeutic use)
  • Male
  • Near Drowning (diagnostic imaging)
  • Persistent Vegetative State (diagnostic imaging, drug therapy)
  • Pyridines (therapeutic use)
  • Radiopharmaceuticals
  • Spinocerebellar Ataxias (diagnostic imaging, drug therapy, microbiology)
  • Stroke (diagnostic imaging, drug therapy, metabolism)
  • Technetium Tc 99m Exametazime
  • Tomography, Emission-Computed, Single-Photon
  • Zolpidem

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