[Hypercholesterolemia as a part of chronic GVHD after allogeneic stem cell transplantation].

Abstract

A 45-year-old female with acute myelogenous leukemia (AML-M6) received an allogeneic stem cell transplantation from an HLA-identical sibling donor in June 2002. Prophylaxis against graft-versus-host disease (GVHD) consisted of cyclosporine (CsA) and short-term methotrexate. Acute GVHD did not occur and CsA was discontinued on day 145 after transplantation. However, soon thereafter she suffered from conjunctivitis, stomatitis and liver dysfunction with hypercholesterolemia and was diagnosed as having chronic GVHD. The liver dysfunction and hypercholesterolemia failed to improve despite the administration of CsA and prednisolone. Atrovastatin was not effective and immunosuppressive therapy for two months including ursodeoxycholic acid finally improved the jaundice and hypercholesterolemia. Although lipid metabolism analysis in this case disclosed the same findings as in other intrahepatic cholestatic liver diseases, the results show that the improvement of hypercholesterolemia in chronic GVHD needs the same treatment as chronic GVHD.

• Authors: Motoko Koyama, Ken-ichi Matsuoka, Yuya Kunisaki, Masami Takeuchi, Kosei Matsue
• Journal: [Rinsho ketsueki] The Japanese journal of clinical hematology (Rinsho Ketsueki) Vol. 45 Issue 10 Pg. 1115-8 (Oct 2004) ISSN: 0485-1439 [Print] Japan
• PMID: 15553047 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Immunosuppressive Agents
• Ursodeoxycholic Acid
• Cyclosporine
• Prednisolone

Topics

• Chronic Disease
• Cyclosporine (therapeutic use)
• Drug Therapy, Combination
• Female
• Graft vs Host Disease (drug therapy, etiology)
• Humans
• Hypercholesterolemia (drug therapy, etiology)
• Immunosuppressive Agents (therapeutic use)
• Leukemia, Myeloid, Acute (therapy)
• Middle Aged
• Prednisolone (therapeutic use)
• Stem Cell Transplantation (adverse effects)
• Transplantation, Homologous
• Treatment Outcome
• Ursodeoxycholic Acid (therapeutic use)