[The effect of fominoben and oxyethyltheophylline in combination on pulmonary function and pulmonary hemodynamics in chronic-obstructive diseases of the airways (author's transl)].

Abstract

Mechanics of breathing, gas exchange and pulmonary hemodynamics were investigated in 10 patients with chronic-obstructive lung diseases before and after treatment with oral doses of 160 mg 3'-chloro-2'-(N-methyl-N-[(morpholino-carbonyl)methyl]-aminomethyl)benzanilide hydrochloride (fominoben, Noleptan) and 300 mg oxyethyltheophylline given three times daily. The data of lung function showed a slight decrease of airway obstruction during the treatment. Hyperinflation of the lung, restriction, gas exchange were not significantly changed on the average. The main effect was an improvement of pulmonary hemodynamics: the pathologically increased mean pressures in the pulmonary artery were normalized after treatment.

• Authors: G Siemon, R Thoma
• Journal: Arzneimittel-Forschung (Arzneimittelforschung) Vol. 28 Issue 4 Pg. 698-700 ( 1978) ISSN: 0004-4172 [Print] Germany
• Vernacular Title: Die Wirkung eines Kombinationspräparats aus Fominoben und Oxyäthyltheophyllin auf Lungenfunktion und pulmonale Hämodynamik bei chronisch obstrucktiven Atemwegserkrankungen.
• PMID: 155459 (Publication Type: English Abstract, Journal Article)

Chemical References

• Drug Combinations
• Morpholines
• Theophylline

Topics

• Chronic Disease
• Drug Combinations
• Female
• Humans
• Lung Diseases, Obstructive (physiopathology)
• Male
• Middle Aged
• Morpholines (administration & dosage, pharmacology)
• Pulmonary Circulation (drug effects)
• Respiration (drug effects)
• Respiratory Function Tests
• Theophylline (administration & dosage, analogs & derivatives, pharmacology)