A randomized, double-blind comparison of lercanidipine 10 and 20 mg in patients with stable effort angina: clinical evaluation of cardiac function by ambulatory ventricular scintigraphic monitoring.

Abstract

We evaluated the antiischemic action and the effects on left ventricular response to exercise of lercanidipine, a long-acting dihydropyridine calcium antagonist, in 23 patients with stable effort angina in a randomized, double-blind, parallel trial. Left ventricular function was assessed during upright bicycle exercise using an ambulatory radionuclide detector for continuous noninvasive monitoring of cardiac function. Exercise was performed under control conditions before (run-in placebo period) and after 2-week treatment with lercanidipine 10 or 20 mg once daily. During the placebo run-in period and at the study end, patients underwent clinical examination, ECG, exercise tests, ambulatory ventricular scintigraphic monitoring (VEST). Results showed that both drug doses increased time to onset of ST segment depression >/=1 mm and peak ST segment depression, with improvement of total exercise duration. Heart rate, blood pressure, and the rate-pressure product did not significantly change with respect to pretreatment value. The left ventricular ejection fraction, indicating contractility state of myocardium, was unchanged at rest and during exercise after both lercanidipine doses. In conclusion, lercanidipine is safe and effective in reducing ischemia in patients with stable effort angina without any deterioration of cardiac function.

• Authors: Domenico Acanfora, Mihai Gheorghiade, Luigi Trojano, Giuseppe Furgi, Antimo Papa, Francesco Cacciatore, Luisa Viati, Francesca Mazzella, Franco Rengo
• Journal: American journal of therapeutics (Am J Ther) 2004 Nov-Dec Vol. 11 Issue 6 Pg. 423-32 ISSN: 1075-2765 [Print] United States
• PMID: 15543081 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Antihypertensive Agents
• Dihydropyridines
• lercanidipine

Topics

• Angina, Unstable (drug therapy)
• Antihypertensive Agents (administration & dosage, adverse effects, therapeutic use)
• Dihydropyridines (administration & dosage, adverse effects, therapeutic use)
• Dose-Response Relationship, Drug
• Double-Blind Method
• Exercise Test (drug effects)
• Female
• Heart Ventricles (diagnostic imaging, physiopathology)
• Humans
• Male
• Middle Aged
• Radionuclide Imaging
• Single-Blind Method
• Ventricular Function, Left (drug effects)