Abstract | OBJECT: METHODS: In this prospective, single-institution, randomized clinical trial, 109 patients with mild head injury and traumatic pneumocephalus were randomly assigned to receive or not receive an antibiotic medication ( ceftriaxone, 1 g given twice a day) until occurrence of meningitis or at least 5 days after trauma. The patients were followed up for 1 month posttrauma. The 109 patients were divided into two groups: 53 were assigned to the prophylactic antibiotics therapy group and 56 to the control group. The overall rate of meningitis was 20.1% and the rates of meningitis in the two groups were not significantly different. The results were the same when adjusted for the patient's Glasgow Coma Scale score, sex, and age, as well as for an intradural location of air, air volume, presence of cerebrospinal fluid ( CSF) rhinorrhea or CSF otorrhea, radiological sign of a skull base fracture, or intracranial hemorrhage. CONCLUSIONS:
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Authors | Behzad Eftekhar, Mohammad Ghodsi, Farideh Nejat, Ebrahim Ketabchi, Babak Esmaeeli |
Journal | Journal of neurosurgery
(J Neurosurg)
Vol. 101
Issue 5
Pg. 757-61
(Nov 2004)
ISSN: 0022-3085 [Print] United States |
PMID | 15540912
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Anti-Bacterial Agents
- Ceftriaxone
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Topics |
- Adult
- Anti-Bacterial Agents
(therapeutic use)
- Antibiotic Prophylaxis
- Ceftriaxone
(therapeutic use)
- Female
- Follow-Up Studies
- Glasgow Coma Scale
- Humans
- Male
- Meningitis, Bacterial
(etiology, prevention & control)
- Middle Aged
- Pneumocephalus
(complications)
- Prospective Studies
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