Abstract |
Hyper- immunoglobulin M ( IgM) syndrome (HIGM) is a rare heterogeneous primary immune deficiency. We describe a patient with HIGM characterized by skewed production of serum IgG subclasses and normal somatic hypermutation. This case may represent a subgroup of HIGM type 4 that is characterized by a biased switching to the V-region proximal constant regions.
|
Authors | G R McLean, K K Miller, J W Schrader, A K Junker |
Journal | Clinical and diagnostic laboratory immunology
(Clin Diagn Lab Immunol)
Vol. 11
Issue 6
Pg. 1192-3
(Nov 2004)
ISSN: 1071-412X [Print] United States |
PMID | 15539528
(Publication Type: Case Reports, Journal Article)
|
Chemical References |
- Immunoglobulin Constant Regions
- Immunoglobulin G
- Immunoglobulin M
- Immunoglobulin Variable Region
- Immunoglobulin mu-Chains
|
Topics |
- Adolescent
- Female
- Gene Rearrangement, B-Lymphocyte
(genetics)
- Humans
- Hypergammaglobulinemia
(blood, genetics, pathology)
- Immunoglobulin Constant Regions
(genetics)
- Immunoglobulin G
(blood)
- Immunoglobulin M
(blood, genetics)
- Immunoglobulin Variable Region
(genetics)
- Immunoglobulin mu-Chains
(genetics)
|