Abstract | BACKGROUND:
Low back pain is a leading reason for primary care visits. Many treatment options are available, but some lack scientific support. OBJECTIVE: The aim of this review was to discuss the etiology of low back pain and the relative risks and benefits of muscle relaxants commonly prescribed for the management of back pain. METHODS: RESULTS: Three trials of carisoprodol (N = 197) were located in the Cochrane Library database. Two double-blind, randomized, placebo-controlled trials evaluating the safety and efficacy of cyclobenzaprine hydrochloride (N = 1405) were identified in the literature. Three double-blind, placebo-controlled trials were identified for metaxalone (N = 428) in 2 reports. The types of adverse events seen with these agents involved the central nervous system, including drowsiness/sedation, fatigue, and dizziness. However, the efficacy of cyclobenzaprine hydrochloride was shown to be independent of its sedative effects, which were dose related. The potential for abuse with carisoprodol is of growing concern. CONCLUSIONS:
|
Authors | Peter P Toth, Jason Urtis |
Journal | Clinical therapeutics
(Clin Ther)
Vol. 26
Issue 9
Pg. 1355-67
(Sep 2004)
ISSN: 0149-2918 [Print] United States |
PMID | 15530999
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Review)
|
Chemical References |
- Muscle Relaxants, Central
- Oxazolidinones
- Amitriptyline
- metaxalone
- Carisoprodol
- cyclobenzaprine
|
Topics |
- Amitriptyline
(adverse effects, analogs & derivatives, therapeutic use)
- Carisoprodol
(adverse effects, therapeutic use)
- Humans
- Low Back Pain
(diagnosis, drug therapy, etiology)
- Muscle Relaxants, Central
(adverse effects, therapeutic use)
- Oxazolidinones
(adverse effects, therapeutic use)
- Randomized Controlled Trials as Topic
- Risk Assessment
|